Alpha Stem Cell Clinic

Clinical Trial Experts

Clinical Trial Experts

Dr. Bota smiling at camera
Daniela A. Bota, M.D., Ph.D.
Senior Associate Dean for Clinical Research
Chief Scientific Officer, UCI Center for Clinical Research
Medical Director, Comprehensive Brain Tumor Program
University of California, Irvine
101 The City Drive South, Bldg. 23
Orange, CA 92868
  • - Dr. Bota is the senior associate dean of clinical research in the School of Medicine and medical director of Neuro-Oncology at the University of California in Irvine.
  • - Dr. Bota’s research is focused on translational research in malignant gliomas. Her clinical interests include the comprehensive treatment of brain tumor patients. She currently serves as a principal investigator for multiple studies including novel chemotherapy agents (marizomib), cellular immunotherapy studies (ERC1671 and AV-GBM-1), and a phase 2 study of Optune in Anaplastic Astrocytoma. Her articles have been published in journals such as Cancer Research, Neurological Oncology, Cancer, CNS Oncology, and the Journal of Neuro-Oncology.

Section 2

Dr. Chen smiling at camera

Jefferson W. Chen, M.D., Ph.D., FACS
Clinical Professor
Director of NeuroTrauma
Director of Neurosurgical Critical Care Fellowship
Department of Neurological Surgery
University of California, Irvine
101 The City Drive South, Pavilion 1, Bldg. 30
Orange, CA 92868


  • - Dr. Chen is a neurosurgeon who is board certified in neurosurgery, neurocritical care and neuro-oncology. He is affiliated with numerous hospitals, including UCI Medical Center and more.
  • - His clinical interests include traumatic brain injury, normal pressure hydrocephalus, stroke and brain tumor.
  • - He is a leader in techniques such as multimodal brain monitoring for traumatic brain injury and the use of brain path technology to access deep-seated lesions.

Section 3

Dr. Dayyani smiling at camera
Farshid Dayyani, M.D., Ph.D.
Associate Clinical Professor
Chao Family Comprehensive Cancer Center
UCI School of Medicine
UC Irvine Health
101 The City Dr. South
Orange, CA 92868
  • - Associate professor at Division of Hematology/Oncology, Department of Medicine, UC Irvine School of Medicine
  • - Dr. Dayyani is a board-certified UCI Health medical oncologist at the UCI Health Chao Family Comprehensive Cancer Center and the adjacent UCI Health H.H. Chao Comprehensive Digestive Disease Center.
  • - Dr. Dayyani’s goal is to bring cutting edge treatments to patients with gastrointestinal cancers through innovative clinical trials.
  • Research interests include clinical research, translational research, colorectal carcinomas, gastrointestinal malignancies.

Section 4

Dr. Groysman smiling at camera
Leonid I. Groysman, M.D.
Associate Clinical Professor
Neurocritical Care Fellowship Director
Departments of Neurology and Neurological Surgery
University of California, Irvine
101 The City Drive South, Pavilion 1, Bldg. 30
Orange, CA 92868
  • - Health neurologist and assistant clinical professor at the Department of Neurology, UCI School of Medicine.
  • - Specialties include neurocritical care and neurology.
  • - Director of stroke studies for the Alpha Stem Cell Clinics (ASCC) and assistant clinical director for the Stem Cell Research Center (SCRC).
  • - Dr. Groysman has been principal investigator and UCI site leader on multiple investigator-initiated and industry-sponsored clinical trials, focused specifically on surgical implantation of stem cell therapeutics in subjects with recent ischemic stroke.
  • - He has been involved in many clinical trials. Out of many, stem cell research is one of them. Stem Cell Clinic provides the necessary infrastructure, and medical and operational expertise to effectively and efficiently drive novel stem cell therapies to clinical trials and ultimately change clinical practice.

Section 5

Dr. Ichii smiling at camera
Hirohito Ichii, M.D.
Pancreas/Islet Transplant Program Director, Division of Transplantation
Department of Surgery
University of California, Irvine
333 City Boulevard West Suite 1205, Orange CA 92868
  • - Associate professor, Division of Transplantation, Department of Surgery, UCI School of Medicine
  • - Specialties include transplant surgery and general surgery
  • - Clinical interests are islet cell transplantation, kidney transplantation, pancreas transplantation

Section 6

Dr. Kong smiling at camera

Xiao-Tang Kong, M.D., Ph.D.
Associate Clinical Professor
Clinical Director, Neuro-Oncology Program
Department of Neurology
UC Irvine School of Medicine
200S. Manchester Ave, Suite 206
Orange, CA 92868

  • - Dr. Kong is a board-certified UCI Health Neuro-Oncology specialist in the diagnosis and management of primary brain tumor, CNS lymphoma, and metastatic cancers of the brain and spinal cord, as well as managing neurological complications from cancers and their therapies.
  • - She is also a neuro-oncology hospitalist who ensures continuity of care for patients during their hospitalization.
  • - Dr. Kong is deeply involved in managing clinical trials for brain and spinal cord tumors

Section 7

Dr. Parekh smiling at camera
Nimisha K. Parekh, MD, MPH, FACG, AGAF                               
Associate ProfessorDepartment of Medicine, Division of Gastroenterology & Hepatology
UC Irvine Health
University of California Irvine
101 The City Drive, City Tower, Suite 400, Zot 4092
Irvine, CA 92868
Clinical Line: 714-456-7358
  • Dr. Nimisha K. Parekh, a board-certified UCI Health internist and gastroenterologist, is director of the UCI Health Inflammatory Bowel Disease (IBD) Program. She believes in an integrated approach to managing inflammatory bowel disease (IBD).
  • Her research interests include outcomes in Crohn’s disease and ulcerative colitis, clinical trials for new drug therapies to treat IBD, women’s issues and the role of ethnicity in disease outcomes.
  • Parekh serves as co-director of the Crohn's and Colitis Foundation of America-Orange County Chapter.

Section 8

Dr. Phielipp smiling at camera
Nicolás Phielipp, M.D.                               
Assistant Professor, Department of Neurology
UC Irvine Health
University of California Irvine
1 Medical Plaza Dr., Suite 1323
Irvine, CA 92697
  • - Dr. Phielipp is an assistant professor in the neurology department at UC Irvine Health.
  • - Research interests include the management of Parkinson's disease and task-specific dystonias such as writer's cramp and musician's, golfer's or tennis player's dystonia. He is also interested in developing techniques to better diagnose Parkinson's disease, understanding the mechanisms involved in deep brain stimulation, and improving the diagnosis and management of movement disorders in general.
  • - Participated in several research projects involving transcranial magnetic stimulation for the treatment of mood and motor symptoms of Parkinson's disease, the mechanism of deep brain stimulation in cervical dystonia, the mechanism of action of botulinum toxin in the treatment of writer's cramp and musician's dystonia and the treatment of psychogenic/functional tremor

Section 9

Dr. Yang smiling at camera
Qin Yang, M.D., P.h.D.
Associate Professor of Medicine, Physiology and BiophysicsDirector, UC Irvine Diabetes Center
Interim Chief, Division of Endocrinology, Diabetes and Metabolism
UC Irvine Diabetes Center
University of California, Irvine
101 The City Drive South, Pavilion 1, Bldg. 30
Orange, CA 92868
  • - Dr. Yang is an assistant professor in the Physiology & Biophysics department at UCI.
  • - His research interest includes epigenetic regulation of insulin resistance and energy expenditure in obesity and type 2 diabetes.
  • The research in his laboratory focuses on identifying novel targets and developing new tools for the treatment of obesity and diabetes. He is particularly interested in understanding epigenetic regulation of energy expenditure and insulin resistance. Dr. Yang's laboratory has developed several animal models to ask questions regarding how epigenetic signatures are altered in obesity and type 2 diabetes, and how the altered epigenetic signatures regulate insulin sensitivity and energy metabolism. Another direction of the laboratory is directly related to transnational medicine. They are developing new tools for drug delivery to metabolic organs such as fat tissue and liver. The goal is to increase metabolic rate selectively in these organs for treating obesity and diabetes.